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MiceProtein

MiceProtein

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Author: Clara Higuera, Katheleen J. Gardiner, Krzysztof J. Cios Source: [UCI](https://archive.ics.uci.edu/ml/datasets/Mice+Protein+Expression) - 2015 Please cite: Higuera C, Gardiner KJ, Cios KJ (2015) Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome. PLoS ONE 10(6): e0129126. Expression levels of 77 proteins measured in the cerebral cortex of 8 classes of control and Down syndrome mice exposed to context fear conditioning, a task used to assess associative learning. The data set consists of the expression levels of 77 proteins/protein modifications that produced detectable signals in the nuclear fraction of cortex. There are 38 control mice and 34 trisomic mice (Down syndrome), for a total of 72 mice. In the experiments, 15 measurements were registered of each protein per sample/mouse. Therefore, for control mice, there are 38x15, or 570 measurements, and for trisomic mice, there are 34x15, or 510 measurements. The dataset contains a total of 1080 measurements per protein. Each measurement can be considered as an independent sample/mouse. The eight classes of mice are described based on features such as genotype, behavior and treatment. According to genotype, mice can be control or trisomic. According to behavior, some mice have been stimulated to learn (context-shock) and others have not (shock-context) and in order to assess the effect of the drug memantine in recovering the ability to learn in trisomic mice, some mice have been injected with the drug and others have not. Classes: ``` * c-CS-s: control mice, stimulated to learn, injected with saline (9 mice) * c-CS-m: control mice, stimulated to learn, injected with memantine (10 mice) * c-SC-s: control mice, not stimulated to learn, injected with saline (9 mice) * c-SC-m: control mice, not stimulated to learn, injected with memantine (10 mice) * t-CS-s: trisomy mice, stimulated to learn, injected with saline (7 mice) * t-CS-m: trisomy mice, stimulated to learn, injected with memantine (9 mice) * t-SC-s: trisomy mice, not stimulated to learn, injected with saline (9 mice) * t-SC-m: trisomy mice, not stimulated to learn, injected with memantine (9 mice) ``` The aim is to identify subsets of proteins that are discriminant between the classes. ### Attribute Information: ``` 1 Mouse ID 2..78 Values of expression levels of 77 proteins; the names of proteins are followed by “_n” indicating that they were measured in the nuclear fraction. For example: DYRK1A_n 79 Genotype: control (c) or trisomy (t) 80 Treatment type: memantine (m) or saline (s) 81 Behavior: context-shock (CS) or shock-context (SC) 82 Class: c-CS-s, c-CS-m, c-SC-s, c-SC-m, t-CS-s, t-CS-m, t-SC-s, t-SC-m ``` ### Relevant Papers: Higuera C, Gardiner KJ, Cios KJ (2015) Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome. PLoS ONE 10(6): e0129126. [Web Link] journal.pone.0129126 Ahmed MM, Dhanasekaran AR, Block A, Tong S, Costa ACS, Stasko M, et al. (2015) Protein Dynamics Associated with Failed and Rescued Learning in the Ts65Dn Mouse Model of Down Syndrome. PLoS ONE 10(3): e0119491.

82 features

class (target)nominal8 unique values
0 missing
GluR4_Nnumeric1079 unique values
0 missing
TIAM1_Nnumeric1075 unique values
3 missing
GluR3_Nnumeric1080 unique values
0 missing
GFAP_Nnumeric1079 unique values
0 missing
Tau_Nnumeric1080 unique values
0 missing
nNOS_Nnumeric1079 unique values
0 missing
ERBB4_Nnumeric1079 unique values
0 missing
ARC_Nnumeric1080 unique values
0 missing
BAX_Nnumeric1080 unique values
0 missing
RRP1_Nnumeric1080 unique values
0 missing
AcetylH3K9_Nnumeric1080 unique values
0 missing
ADARB1_Nnumeric1080 unique values
0 missing
S6_Nnumeric1080 unique values
0 missing
CDK5_Nnumeric1080 unique values
0 missing
pPKCG_Nnumeric1080 unique values
0 missing
pGSK3B_Nnumeric1080 unique values
0 missing
P70S6_Nnumeric1080 unique values
0 missing
NUMB_Nnumeric1080 unique values
0 missing
pP70S6_Nnumeric1076 unique values
3 missing
RAPTOR_Nnumeric1077 unique values
3 missing
pS6_Nnumeric1080 unique values
0 missing
Behaviornominal2 unique values
0 missing
Treatmentnominal2 unique values
0 missing
Genotypenominal2 unique values
0 missing
CaNA_Nnumeric1080 unique values
0 missing
H3MeK4_Nnumeric810 unique values
270 missing
EGR1_Nnumeric870 unique values
210 missing
H3AcK18_Nnumeric900 unique values
180 missing
SYP_Nnumeric1079 unique values
0 missing
pCFOS_Nnumeric1005 unique values
75 missing
IL1B_Nnumeric1080 unique values
0 missing
BCL2_Nnumeric795 unique values
285 missing
BAD_Nnumeric866 unique values
213 missing
SHH_Nnumeric1080 unique values
0 missing
pGSK3B_Tyr216_Nnumeric1080 unique values
0 missing
Ubiquitin_Nnumeric1080 unique values
0 missing
SNCA_Nnumeric1079 unique values
0 missing
PSD95_Nnumeric1080 unique values
0 missing
pCASP9_Nnumeric1080 unique values
0 missing
P3525_Nnumeric1080 unique values
0 missing
pELK_Nnumeric1077 unique values
3 missing
AKT_Nnumeric1077 unique values
3 missing
pRSK_Nnumeric1077 unique values
3 missing
pPKCAB_Nnumeric1077 unique values
3 missing
pNR2B_Nnumeric1077 unique values
3 missing
pNR2A_Nnumeric1077 unique values
3 missing
pNR1_Nnumeric1077 unique values
3 missing
pMEK_Nnumeric1077 unique values
3 missing
PKCA_Nnumeric1077 unique values
3 missing
pJNK_Nnumeric1076 unique values
3 missing
pERK_Nnumeric1077 unique values
3 missing
BRAF_Nnumeric1077 unique values
3 missing
pCREB_Nnumeric1077 unique values
3 missing
pCAMKII_Nnumeric1077 unique values
3 missing
pBRAF_Nnumeric1075 unique values
3 missing
pAKT_Nnumeric1076 unique values
3 missing
NR2A_Nnumeric1077 unique values
3 missing
NR1_Nnumeric1077 unique values
3 missing
BDNF_Nnumeric1077 unique values
3 missing
ITSN1_Nnumeric1076 unique values
3 missing
DYRK1A_Nnumeric1077 unique values
3 missing
APP_Nnumeric1077 unique values
3 missing
pNUMB_Nnumeric1077 unique values
3 missing
NR2B_Nnumeric1077 unique values
3 missing
AMPKA_Nnumeric1075 unique values
3 missing
DSCR1_Nnumeric1077 unique values
3 missing
pMTOR_Nnumeric1077 unique values
3 missing
P38_Nnumeric1075 unique values
3 missing
MTOR_Nnumeric1077 unique values
3 missing
SOD1_Nnumeric1077 unique values
3 missing
Bcatenin_Nnumeric1062 unique values
18 missing
MouseID (row identifier)nominal1080 unique values
0 missing
RSK_Nnumeric1074 unique values
3 missing
TRKA_Nnumeric1075 unique values
3 missing
MEK_Nnumeric1072 unique values
7 missing
JNK_Nnumeric1077 unique values
3 missing
GSK3B_Nnumeric1077 unique values
3 missing
ERK_Nnumeric1077 unique values
3 missing
ELK_Nnumeric1062 unique values
18 missing
CREB_Nnumeric1073 unique values
3 missing
CAMKII_Nnumeric1077 unique values
3 missing
Show all 82 features

62 properties

NumberOfInstances
1080
Number of instances (rows) of the dataset.
NumberOfFeatures
82
Number of attributes (columns) of the dataset.
NumberOfClasses
8
Number of distinct values of the target attribute (if it is nominal).
NumberOfMissingValues
1396
Number of missing values in the dataset.
NumberOfInstancesWithMissingValues
528
Number of instances with at least one value missing.
NumberOfNumericFeatures
77
Number of numeric attributes.
NumberOfSymbolicFeatures
5
Number of nominal attributes.
Quartile1MutualInformation
1
First quartile of mutual information between the nominal attributes and the target attribute.
PercentageOfBinaryFeatures
3.66
Percentage of binary attributes.
PercentageOfInstancesWithMissingValues
48.89
Percentage of instances having missing values.
PercentageOfMissingValues
1.58
Percentage of missing values.
PercentageOfNumericFeatures
93.9
Percentage of numeric attributes.
PercentageOfSymbolicFeatures
6.1
Percentage of nominal attributes.
Quartile1AttributeEntropy
1
First quartile of entropy among attributes.
Quartile1KurtosisOfNumericAtts
0.21
First quartile of kurtosis among attributes of the numeric type.
Quartile1MeansOfNumericAtts
0.19
First quartile of means among attributes of the numeric type.
StdvNominalAttDistinctValues
3
Standard deviation of the number of distinct values among attributes of the nominal type.
Quartile1SkewnessOfNumericAtts
0.03
First quartile of skewness among attributes of the numeric type.
Quartile1StdDevOfNumericAtts
0.03
First quartile of standard deviation of attributes of the numeric type.
Quartile2AttributeEntropy
1
Second quartile (Median) of entropy among attributes.
Quartile2KurtosisOfNumericAtts
0.89
Second quartile (Median) of kurtosis among attributes of the numeric type.
Quartile2MeansOfNumericAtts
0.38
Second quartile (Median) of means among attributes of the numeric type.
Quartile2MutualInformation
1
Second quartile (Median) of mutual information between the nominal attributes and the target attribute.
Quartile2SkewnessOfNumericAtts
0.46
Second quartile (Median) of skewness among attributes of the numeric type.
Quartile2StdDevOfNumericAtts
0.07
Second quartile (Median) of standard deviation of attributes of the numeric type.
Quartile3AttributeEntropy
1
Third quartile of entropy among attributes.
Quartile3KurtosisOfNumericAtts
2.29
Third quartile of kurtosis among attributes of the numeric type.
Quartile3MeansOfNumericAtts
0.79
Third quartile of means among attributes of the numeric type.
Quartile3MutualInformation
1
Third quartile of mutual information between the nominal attributes and the target attribute.
Quartile3SkewnessOfNumericAtts
0.97
Third quartile of skewness among attributes of the numeric type.
Quartile3StdDevOfNumericAtts
0.23
Third quartile of standard deviation of attributes of the numeric type.
AutoCorrelation
0.99
Average class difference between consecutive instances.
MeanMeansOfNumericAtts
0.67
Mean of means among attributes of the numeric type.
ClassEntropy
2.99
Entropy of the target attribute values.
Dimensionality
0.08
Number of attributes divided by the number of instances.
EquivalentNumberOfAtts
3
Number of attributes needed to optimally describe the class (under the assumption of independence among attributes). Equals ClassEntropy divided by MeanMutualInformation.
MajorityClassPercentage
13.89
Percentage of instances belonging to the most frequent class.
MajorityClassSize
150
Number of instances belonging to the most frequent class.
MaxAttributeEntropy
1
Maximum entropy among attributes.
MaxKurtosisOfNumericAtts
62.55
Maximum kurtosis among attributes of the numeric type.
MaxMeansOfNumericAtts
3.84
Maximum of means among attributes of the numeric type.
MaxMutualInformation
1
Maximum mutual information between the nominal attributes and the target attribute.
MaxNominalAttDistinctValues
8
The maximum number of distinct values among attributes of the nominal type.
MaxSkewnessOfNumericAtts
4.74
Maximum skewness among attributes of the numeric type.
MaxStdDevOfNumericAtts
1.3
Maximum standard deviation of attributes of the numeric type.
MeanAttributeEntropy
1
Average entropy of the attributes.
MeanKurtosisOfNumericAtts
4.54
Mean kurtosis among attributes of the numeric type.
NumberOfBinaryFeatures
3
Number of binary attributes.
MeanMutualInformation
1
Average mutual information between the nominal attributes and the target attribute.
MeanNoiseToSignalRatio
0
An estimate of the amount of irrelevant information in the attributes regarding the class. Equals (MeanAttributeEntropy - MeanMutualInformation) divided by MeanMutualInformation.
MeanNominalAttDistinctValues
3.5
Average number of distinct values among the attributes of the nominal type.
MeanSkewnessOfNumericAtts
0.79
Mean skewness among attributes of the numeric type.
MeanStdDevOfNumericAtts
0.16
Mean standard deviation of attributes of the numeric type.
MinAttributeEntropy
1
Minimal entropy among attributes.
MinKurtosisOfNumericAtts
-0.74
Minimum kurtosis among attributes of the numeric type.
MinMeansOfNumericAtts
0.12
Minimum of means among attributes of the numeric type.
MinMutualInformation
1
Minimal mutual information between the nominal attributes and the target attribute.
MinNominalAttDistinctValues
2
The minimal number of distinct values among attributes of the nominal type.
MinSkewnessOfNumericAtts
-0.88
Minimum skewness among attributes of the numeric type.
MinStdDevOfNumericAtts
0.01
Minimum standard deviation of attributes of the numeric type.
MinorityClassPercentage
9.72
Percentage of instances belonging to the least frequent class.
MinorityClassSize
105
Number of instances belonging to the least frequent class.
Show all 62 properties

18 tasks

Learning Curve on MiceProtein
0 runs - estimation_procedure: 10-fold Learning Curve - target_feature: class
Learning Curve on MiceProtein
0 runs - estimation_procedure: 10-fold Learning Curve - target_feature: class
Learning Curve on MiceProtein
0 runs - estimation_procedure: 10-fold Learning Curve - target_feature: class
Learning Curve on MiceProtein
0 runs - estimation_procedure: 10-fold Learning Curve - target_feature: class
Learning Curve on MiceProtein
0 runs - estimation_procedure: 10-fold Learning Curve - target_feature: class
Learning Curve on MiceProtein
0 runs - estimation_procedure: 10-fold Learning Curve - target_feature: class
Learning Curve on MiceProtein
0 runs - estimation_procedure: 10-fold Learning Curve - target_feature: class
Supervised Data Stream Classification on MiceProtein
0 runs - estimation_procedure: Interleaved Test then Train - target_feature: class
Clustering on MiceProtein
0 runs
Clustering on MiceProtein
0 runs - estimation_procedure: 50 times Clustering
Clustering on MiceProtein
0 runs - estimation_procedure: 50 times Clustering
Clustering on MiceProtein
0 runs - estimation_procedure: 50 times Clustering
Clustering on MiceProtein
0 runs - estimation_procedure: 50 times Clustering
Clustering on MiceProtein
0 runs - estimation_procedure: 50 times Clustering
Clustering on MiceProtein
0 runs - estimation_procedure: 50 times Clustering
Clustering on MiceProtein
0 runs - estimation_procedure: 50 times Clustering
Clustering on MiceProtein
0 runs - estimation_procedure: 50 times Clustering
Clustering on MiceProtein
0 runs - estimation_procedure: 50 times Clustering
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